Premature menopause, premature ovarian failure, and poor pregnancy history all increase the risk of cardiovascular disease in women. Female menopause is associated with central obesity, insulin resistance, atherosclerosis, etc.; hormone therapy is the most effective way to relieve menopausal symptoms, but the pros and cons should be fully understood, especially for women at risk of cardiovascular disease. A healthy lifestyle, diet and regular exercise are the recommended menopausal management programs. Joining functional medicine to fully regulate female endocrine will be the best health program.